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  • International Meeting for Evolution of Reproductive Biology and Task of Frontiers: Trajectory and Prospects of IVF, Stem Cell and Epigenetic Studies

  • This International Meeting is sponsored by the Ministry of Education, Culture, Sports, Science and Technology in Japan (MEXT) and organized by the Society for Reproduction and Development (SRD).
  • AIINA, Morioka, Iwate, Japan
  • 13–15 September 2011.

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  • During the last 50 years, in vitro fertilization (IVF) and embryo transfer (ET) studies and technologies have developed remarkably, and these techniques have expanded the scope and opened various new fields in reproductive biology as well as molecular biology. SRD has contributed to this progress; in the early 1960s, the non-surgical ET method was developed, in the mid-1980s, an IVM-IVF bovine calf was produced, in 2000, a bovine calf was conceived using a somatic cell nuclear transferred ovum. Now these remarkable advances reflect a new insight into reproductive biology and biological issues such as embryonic stem cells, induced stem cells and epigenetic studies. In this symposium, we will review the historical and evolutional development of in vitro embryonic studies and discuss the future of reproductive biology. This meeting focuses on IVF, ET, Stem cells, Epigenetics and feto-maternal communication. We would like to express our sincere appreciation to the invited speakers and chairpersons for their vigorous cooperation, young scientists for posters and all participants for active discussion. We also acknowledge the MEXT for funding this international meeting. All contributions encourage the further development of Reproductive Biology.

  • President of Meeting: Noboru MANABE (The University of Tokyo)
  • Scientific Committee: Kazuyoshi HASHIZUME (Chair) (Iwate University)
  • Yoshiaki IZAIKE (Iwate University)
  • Hiroyuki KANEKO (National Institute of Agrobiological Sciences)
  • Kunio SHIOTA (The University of Tokyo)
  • Advisors for Scientific Committee: Fuller W. BAZER (Texas A&M University)
  • Michael J. SOARES (University of Kansas Medical Center)
  • Thomas E. SPENCER (Washington State University)
  • Koji YOSHINAGA (National Institutes of Health)
  • Program Committee: Kazuhiko IMAKAWA (The University of Tokyo)
  • Yuji HIRAO (Tohoku Agricultural Research Center, National Agriculture and Food Research Organization)
  • Kazuhiro KIKUCHI (National Institute of Agrobiological Sciences)
  • Keiichiro KIZAKI (Iwate University)
  • Atsuo OGURA (RIKEN-Bioresource Center)
  • Takeshi OSAWA (Iwate University)
  • Ken SAWAI (Iwate University)
  • Hiroshi SUZUKI (Obihiro University of Agriculture and Veterinary Medicine)
  • Toru TAKAHASHI (National Institute of Agrobiological Sciences)
  • Satoshi TANAKA (The University of Tokyo)
  • Nobuhiko YAMAUCHI (Kyushu University)

  • SRD
  • Secretary: Hiroko TSUKAMURA (Chair) (Nagoya University)
  • Naoko INOUE (Nagoya University)
  • Yoshihisa UENOYAMA (Nagoya University)
  • Treasurer: Takashi MIYANO (Chair) (Kobe University)
  • Hiroshi HARAYAMA (Kobe University)
  • Local Organized Committee: Norio YAMAGISHI (Chair) (Iwate University)
  • Bhuminand DEVKOTA (Iwate University)
  • Tsutomu HASHIZUME (Iwate University)
  • Toh-ichi HIRATA (Iwate University)
  • Kosuke IGA (Tohoku Agricultural Research Center, National Agriculture and Food Research Organization)
  • Kazuei MATSUBARA (Iwate University)
  • Naoki TAKENOUCHI (Tohoku Agricultural Research Center, National Agriculture and Food Research Organization)
  • Manabu YAMAGUCHI (Tohoku Agricultural Research Center, National Agriculture and Food Research Organization)
  • Miharu YONAI (Tohoku Agricultural Research Center, National Agriculture and Food Research Organization)
  • [Abstracts (PDF)]


  • Tuesday, September 13

  • Opening Remark International Symposium for SRD
  • Kazuyoshi HASHIZUME (Iwate University)

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  • Session 1. Frontiers for In Vitro Fertilization, Embryo Culture and Embryo Transfer
  • Chairpersons: Takashi NAGAI (National Institute of Livestock and Grassland Science),
  • Atsuo OGURA (RIKEN BioResource Center)
  • IS1-1: Yutaka TOYODA (Obihiro University of Agriculture and Veterinary Medicine)
  • “A Historical Perspective on IVF, In Vitro Embryo Culture and ET in Japan”
  • IS1-2: Christopher G. GRUPEN (The University of Sydney)
  • “Frontiers of IVF in Livestock Species: Factors Affecting Efficiency”
  • IS1-3: Hiroshi SUZUKI (Obihiro University of Agriculture and Veterinary Medicine)
  • “Puppies from Frozen Embryos”
  • IS1-4: George E. SEIDEL, JR. (Colorado State University)
  • “Sexing Mammalian Sperm”
  • IS1-5: Jean-Paul RENARD (INRA-CNRS-ENVA)
  • “From a Functional to a Molecular Assessment of Totipotency”
  • IS1-6: Kazuhiro KIKUCHI (National Institute of Agrobiological Sciences)
  • “Abnormality and the Restoration of In Vitro-produced Porcine Embryos”

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  • Plenary Speech Metropolitan
  • Chairperson: Noboru MANABE (The University of Tokyo)
  • IS-PS: Ryuzo YANAGIMACHI (University of Hawaii Medical School)
  • “Fertilization Studies and Assisted Fertilization in Mammals: Their Development and Future”


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  • Wednesday, September 14

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  • Session 2. Embryonic Cell Differentiation and Functions in Feto-maternal Dialogue
  • Chairpersons: Masashi TAKAHASHI (Kyushu Okinawa Agricultural Research Center),
  • Hiromichi MATSUMOTO (Utsunomiya University)
  • IS2-1: Atsuo OGURA (RIKEN BioResource Center)
  • “Critical Involvement of Aberrant X Chromosome Inactivation in the Defective Postimplantation Development of Cloned Embryos”
  • IS2-2: (Withdrawn)
  • IS2-3: Satoshi TANAKA (The University of Tokyo)
  • “Difference in the DNA Methylation Status Arises after Segregation of Trophoblast and Embryonic Cell Lineages”
  • IS2-4: Michael J. SOARES (University of Kansas Medical Center)
  • “Regulatory Pathway Controlling Uterine Spiral Artery Remodeling”
  • Chairpersons: Kazuhiko IMAKAWA (The University of Tokyo),
  • Satoshi TANAKA (The University of Tokyo)
  • IS2-5: Toru TAKAHASHI (National Institute of Agrobiological Sciences)
  • “Novel Proteins Affecting Cell Proliferation and Angiogenesis of Bovine Placenta”
  • IS2-6: Fuller W. BAZER (Texas A&M University)
  • “Select Nutrients in the Uterine Lumen of Sheep and Pigs Affect Conceptus Development”
  • IS2-7: Niamh FORDE (University College Dublin)
  • “Gene Expression in the Bovine Endometrium: The Effects of Altered Progesterone Concentrations and the Presence of the Conceptus”
  • IS2-8: Nobuhiko YAMAUCHI (Kyushu University)
  • “Development of the Endometrial Spheroids as a Model for Implantation In Vitro”
  • IS2-9: Thomas E. SPENCER (Washington State University)
  • “Endogenous Retroviruses: A Model System for Understanding Physiological Adaptation to a Rapidly Evolving Ruminant Genome”
  • Summary of the Day: Koji YOSHINAGA (National Institutes of Health)
  • “Future of Implantation Studies”


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  • Thursday, September 15

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  • Session 3. Stem Cells and Epigenetics
  • Chairperson: Kunio SHIOTA (The University of Tokyo)
  • IS3-1: Shintaro YAGI (The University of Tokyo)
  • “DNA Methylation Profiling by Tissue-dependent and Differentially Methylated Regions (T-DMRs) in Pluripotent Stem Cells: Insights into Genome Organization”
  • IS3-2: (Withdrawn)
  • IS3-3: Yoshinori SEKI (Albert Einstein College of Medicine)
  • “Exposure to a Maternal High Fat Milieu Alters the Hepatic Epigenome in Mice”
  • IS3-4: Masako SUZUKI (Albert Einstein College of Medicine)
  • “Genome-wide DNA Methylation Profiling of Male and Female Mouse Embryonic Stem Cell Differentiation Using Massively Parallel Sequencing”
  • IS3-5: Kenichiro HATA (National Research Institute for Child Health and Development)
  • “Epigenetics of Human Reproduction and Developmental Abnormality”
  • Special Lecture
  • IS3-6: Scott COONROD (Cornell University)
  • “Role for PAD Enzymes in Chromatin Structure, Gene Regulation, and Disease”
  • Closing Remark for International Meeting
  • Noboru MANABE (The University of Tokyo)


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  • Tuesday–Thursday, September 13–15

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  • Poster Session
  • ISP1: Momo NAKANISHI, Koji HAYAKAWA, Kunio SHIOTA, Satoshi TANAKA (The University of Tokyo)
  • “Trophoblast-specific DNA Methylation Occurs after the Segregation of Trophectoderm and Inner Cell Mass in Mouse Periimplantation Embryo”
  • ISP2: Vibuntita CHANKITISAKUL1,2, Tamas SOMFAI1, Yasushi INABA1, Mongkol TECHAKUMPHU2, Takashi NAGAI1 (1National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization; 2Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, Thailand)
  • “ATP Content in Bovine Oocytes May not Determine the Timing of First Cleavage and Further Developmental Competence after IVF”
  • ISP3: Hiroyuki WATANABE1, Hiroshi SUZUKI2, Yutaka FUKUI2, Hiroyuki TATENO1 (1Asahikawa Medical University, 2Obihiro University of Agriculture and Veterinary Medicine)
  • “Excessive Pre-treatment of Mouse Spermatozoa with DNA Non-interacting Agents Causes Zygotic Chromosomal Damage”
  • ISP4: Toshihiro KONNO, Sachiko YAMAKOSHI, Rulan BAI, Takashi CHAEN, Mahiro EGASHIRA, Nana NOMURA, Toshihiro SAKURAI, Kazuhiko IMAKAWA (Graduate School of Agricultural and Life Sciences, The University of Tokyo)
  • “Epithelial-mesenchymal Transition of Trophectoderm Cells during Embryo Implantation”
  • ISP5: Hanako BAI1, Toshihiro SAKURAI1, So NAKAGAWA2, Toshihiro KONNO1, Takayuki MIYAZAWA3, Takashi GOJOBORI2, Kazuhiko IMAKAWA1 (1Graduate school of Agricultural and Life Sciences, The University of Tokyo; 2National institute of Genetics; 3Institute for Virus Research, Kyoto University)
  • “Identification of Endogenous Retroviruses Derived-gene Possessing a Zinc Finger Like Sequence during Bovine Peri-attachment Period”
  • ISP6: Thanh Quang DANG-NGUYEN1,2, Nguyen VIET LINH2,3, Rosa MINOIA5, Masahiro KANEDA1, Tamas SOMFAI1, Seiki HARAGUCHI1, Satoshi AKAGI1, Kazuhiro KIKUCHI4, Michiko NAKAI4, Atsushi TAJIMA2 and Takashi NAGAI1 (1National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization; 2University of Tsukuba; 3University of Tokyo; 4National Institute of Agrobiological Sciences; 5University of Bari, Italy)
  • “Effect of Naloxone, a Mu-opioid Receptor Antagonist, on Oocyte Maturation and Embryonic Eevelopment in Pigs”


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  • [Abstracts (PDF)]